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Come è noto, la Sindrome dell’ovaio policistico (o PCOS), è caratterizzata dalla presenza di cisti ovariche e dal conseguente squilibrio ormonale in età riproduttiva.
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A livello ormonale, infatti, la PCOS rileva un calo di estrogeni e un incremento di androgeni (Testosterone). (1.2)
L’iperandrogenismo che ne consegue, può dar luogo a livello dermatologico, ad ACNE, IRSUTISMO, ALOPECIA
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Bisogna quindi agire sulle cause che generano questi squilibri ormonali, per migliorare le suddette patologie.
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Eziopatogenesi dell’Acne in donne con PCOS:
L’aumento di Testosterone, stimolando l’iperproduzione sebacea, genera la formazione di comedoni nelle aree più sensibili agli sbalzi ormonali. L’acne infatti, ha un’incidenza tra le giovani donne con PCOS, pari al 37% (4)
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TERAPIE:
Benché l’utilizzo della pillola contraccettiva sia tutt’ora il trattamento di riferimento nella terapia della PCOS, sempre più spesso, soprattutto nei casi “borderline” della prima adolescenza, si ricorre ad integratori terapeutici a base di Myo-inositolo ed acido folico
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Inocomplex è la risposta efficace al problema della Sindrome dell’ovaio policistico ed ai suoi risvolti dermatologici
- 200 mcg. di Acido Folico e 2100 mg. di Myo-Inositolo per compressa da 3 gr.
- 60 compresse orosolubili
- rapida assimilazione già al livello sublinguale, rendendo subito biodisponibili i principi attivi
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Il 70% dei pazienti con PCOS soffre di insulino-resistenza
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L’inositolo è uno zucchero carbociclico presente in alcuni alimenti e sintetizzato anche dal fegato. Alcuni autori viceversa, lo definiscono come vitamina B7 (tuttavia, non può essere considerato propriamente una vitamina, poiché a differenza delle vitamine, è sintetizzato anche dal corpo umano).
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Il myo inositolo, la forma più usata di inositolo, una volta assimilato, tende a convertirsi in una molecola nota come “inositolo trifosfato”.
Questa molecola regola l’insulino resistenza e più in generale, gli squilibri ormonali (permettendo al corpo di usare il glucosio per produrre energia, senza usare alti livelli di insulina).
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BENEFICI:
- Diminuzione della disfunzione ormonale
- Riduzione dell’insulino- resistenza e del Testosterone
- Ripristino della normale funzionalità ovarica
- Riduzione dei problemi dermatologici annessi alla PCOS
1-The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-47
2-Azziz R, Carmina E, Dewailly D et al. POSITION STATEMENT: Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society 3
3- Guideline. J Clin Endocrinol Metab 2006; 91: 4237-4245. 3 -Ferriman DM, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol 1961;21:1440–1447
Kelekci KH1, Kelekci S, Incki K, Ozdemir O, Yilmaz B.
Ovarian morphology and prevalence of polycystic ovary syndrome in reproductive aged women with or without mild acne
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